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Office-based Treatment of OAB

Urgent PC neuromodulation system is designed for the treatment of overactive bladder and associated symptoms of urinary urgency, urinary frequency and urge incontinence.

The Urgent PC advantage

  • Minimally invasive treatment easily administered in a clinic – No need for hospitalisation or anaesthesia
  • Well-tolerated by patients with few associated side-effects
  • Can treat both OAB and Faecal Incontinence
  • Suitable for patients when conventional therapies have failed
  • May be used alone or with other therapies

A simple procedure

  • Provides percutaneous tibial nerve stimulation: a slim needle electrode, inserted near the tibial nerve, carries electric impulses from a hand-held stimulator to the sacral plexus
  • 30-minute treatment sessions
  • After the 12 initial treatments, some patients may need occasional sessions to sustain symptom relief
  • Most common side-effects are temporary and include mild pain or skin inflammation at or near the stimulation site

Results supported by clinical evidence*

  • Patient response rates of up to 80%
  • Documented reductions in daytime voiding frequency, night-time voiding frequency and leakage episodes
  • Statistically superior to validated sham therapy in a double-blind RCT
  • Results maintained at a three year mean follow-up when initial series was followed by maintenance therapy
  • In a double-blind placebo study, 71% of patients responded (defined as >50% reduction in voids per day) to treatment with Urgent PC.
  • According to this criteria, no patients in the placebo group were considered responders.

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1. Peters, K., Carrico, D. (2013). Clinical insights into percutaneous tibial nerve stimulation (PTNS) versus sham therapy for the treatment of overactive bladder syndrome (OAB): secondary analysis of the SUmiT Trial. Poster presentation, SUFU winter meeting, Las Vegas, NV.
2. Leong, F.C., McLennan, M.T., Barr, S.A., & Steele, A.C. (2011). Posterior tibial nerve stimulation in patients who have failed anticholinergic therapy: efficacy and time to response. Female Pelvic Med Reconstr Surg, 17(2), 74-5.
3. Peters, K.M., Carrico, D.J., Perez-Marrero, R.A., Khan, A.U., Wooldridge, L.S., Davis, G.L., et al. (2010). Randomized trial of percutaneous tibial nerve stimulation versus sham efficacy in the treatment of overactive bladder syndrome: results from the SUmiT Trial. J Urol, 183, 1438–43.
4. Peters, K.M., Leong, F.C., Shobeiri, S.A., MacDiarmid, S.A., Rovner, E.S., Wooldridge, L.S., et al. (2009). A randomized trial of percutaneous tibial nerve stimulation versus extended-release tolterodine: results from the Overactive Bladder Innovative Therapy trial. J Urol, 182, 1055-61.
5. Vecchioli-Scaldazza, C., Morosetti, C., Beouz, A., Giannubilo, W., Ferrara, V. (2013). Solifenacin succinate versus percutaneous tibial nerve stimulation in women with overactive bladder syndrome: results of a randomized controlled crossover study. Gynecol Obstet Invest, 75(4), 230-4.
6. Peters, K.M., Carrico, D.J., Wooldridge, L.S., Miller, C.J. & MacDiarmid, S.A. (2013). Percutaneous tibial nerve stimulation (PTNS) for the long-term treatment of overactive bladder: three-year results of the STEP Study. J Urol, 189(6), 2194-2201.
7. Finazzi-Agrò, E., Petta, F., Sciobica, F., Pasqualetti, P., Musco, S., & Bove, P. (2010). Percutaneous tibial nerve stimulation effects on detrusor overactivity incontinence are not due to a placebo effect: a randomized, double-blind, placebo controlled trial. J Urol, 184, 2001-06.
8. MacDiarmid, S.A., & Staskin, D.R. (2009). Percutaneous tibial nerve stimulation (PTNS): a literature-based assessment. Curr Bld Dysf Rept, 4, 29-33.
9. Burton, C., Sajia, A., & Latthe, P.M. (2012). Effectiveness of percutaneous posterior tibial nerve stimulation for overactive bladder: a systemic review and meta-analysis. Neurourol Urodyn, 31(8), 1206-16.

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